Description consists of mesothelioma cancer histology-cels epithelial cells or fibrous cells and can be both. Forms of epithelial mesothelioma cell histology sometimes causes confusion with Anaplastic peripheral lung carcinomas or metastatic carcinomas. Business diagnosis of mesothelioma with pleural cytology or needle biopsy is often not successful. This makes it a little difficult to distinguish mesotelioma with adenocarcinoma on small tissue specimens.
Thoracoscopy action is quite useful in obtaining specimens for diagnostic purposes. Mesothelioma cancer examination on the operation and use of stain or electron microscopy can often help. Reported the most useful special stain to reveal histological mesothelioma, a special stain that includes acid-Schiff diastase, hyaluronic acid, mucicarmine, CEA, and Leu M1.
Histological mesothelioma cells is influenced to progonosis mesothelioma, and most research indicates that patients mesotelioma with epithelial cells provide a better prognosis than the histological picture of mesothelioma sarcomatous or mixed cell.
Friday, May 28, 2010
The vaccine proved safe Mesothelioma
According to a study recently conducted by a cancer research laboratory in the Netherlands, the newest of new vaccines to prevent and treat mesothelioma mesothelioma, a form of cancer that comes from exposure to asbestos. The researchers have tested the vaccine on 10 patients who had been diagnosed with mesothelioma, with all of them showed increased levels of antibodies against the disease and three of them showed that the tumor has decreased in size.
The study, published in American Journal of Respiratory and Critical Care Medicine, explains how vaccines work by creating dendritic cells antigen in malignant mesothelioma tumors in the lining fluid in the lungs of the patient. Dr Joachim Aerts, also the author of the study and lung specialist at the Erasmus Medical Center in Rotterdam, said that the approach using the patient's immune system to attack tumors and is useful for creating immunity to the disease, compared with conventional radiation or chemotherapy treatments.
Dr. Aerts said that this is one of a relatively new form of treatment called immunotherapy for cancer. Mesothelioma vaccine can be used and relatively safe, with minimal side effects when compared with current treatment methods. He expressed the hope that further study could improve the survival rates of patients with diseases mesotelioma. Currently, patients diagnosed with mesothelioma, the prognosis of his life just to stay less than two years.
Patients who had been exposed to asbestos typically do not show symptoms of mesothelioma for several years or even decades, after the initial exposure period. At that time, mesothelioma will continue to run metastases in the lung, and seep into other organs. Another aspect of this study is that the vaccine could be a direct treatment for workers exposed to asbestos.
Although the side effects shown by the patients in this study was not as bad as experienced by patients undergoing chemotherapy or radiation treatments, one of the potential effects derived from changes of the immune system of patients during immunotherapy. The study noted that patients recover quickly and shows no signs of autoimmune disease related.
Dr. Aerts notes that there is potential for problems exist on immunosuppressive disorders. He said that the main problem for the treatment of mesothelioma is a tumor to create an environment in pleural mesothelium which can reduce the effects of the vaccine. He mentioned that the next step in vaccine development is how to provide immunosuppressive around to improve the effectiveness of cancer treatment.
Dr. Aerts and her fellow researchers have done some tests on the effects on dendritic cells and how they may affect cancer tumors in mice. Previous studies have shown that vaccination produces antibodies needed to destroy malignant cells and keep the healthy tissue around it to produce specific immunity.
The study, published in American Journal of Respiratory and Critical Care Medicine, explains how vaccines work by creating dendritic cells antigen in malignant mesothelioma tumors in the lining fluid in the lungs of the patient. Dr Joachim Aerts, also the author of the study and lung specialist at the Erasmus Medical Center in Rotterdam, said that the approach using the patient's immune system to attack tumors and is useful for creating immunity to the disease, compared with conventional radiation or chemotherapy treatments.
Dr. Aerts said that this is one of a relatively new form of treatment called immunotherapy for cancer. Mesothelioma vaccine can be used and relatively safe, with minimal side effects when compared with current treatment methods. He expressed the hope that further study could improve the survival rates of patients with diseases mesotelioma. Currently, patients diagnosed with mesothelioma, the prognosis of his life just to stay less than two years.
Patients who had been exposed to asbestos typically do not show symptoms of mesothelioma for several years or even decades, after the initial exposure period. At that time, mesothelioma will continue to run metastases in the lung, and seep into other organs. Another aspect of this study is that the vaccine could be a direct treatment for workers exposed to asbestos.
Although the side effects shown by the patients in this study was not as bad as experienced by patients undergoing chemotherapy or radiation treatments, one of the potential effects derived from changes of the immune system of patients during immunotherapy. The study noted that patients recover quickly and shows no signs of autoimmune disease related.
Dr. Aerts notes that there is potential for problems exist on immunosuppressive disorders. He said that the main problem for the treatment of mesothelioma is a tumor to create an environment in pleural mesothelium which can reduce the effects of the vaccine. He mentioned that the next step in vaccine development is how to provide immunosuppressive around to improve the effectiveness of cancer treatment.
Dr. Aerts and her fellow researchers have done some tests on the effects on dendritic cells and how they may affect cancer tumors in mice. Previous studies have shown that vaccination produces antibodies needed to destroy malignant cells and keep the healthy tissue around it to produce specific immunity.
Mesothelioma Treatment by Photodynamic Therapy
Photodynamic therapy or fotodinamis therapy is one type of mesothelioma treatment is very promising future. This method combines three separate elements are nontoxic, photosensitizing compound, oxygen and visible light. Fotodinamis therapy targeting the cancerous mesothelioma cells. Usually given during or after surgery to remove the remaining parts of the tumor.
Unlike the case with chemotherapy and radiation, which tends to have a burning effect on the patient's body, Photodynamic Therapy provides a clear advantage that it does not kill healthy cells-non-cancerous cells. This means that the side effects of cancer treatment can be reduced and certainly mesotelioma mesothelioma prognosis will be better.
In America, Photodynamic Therapy has been approved by the Food and Drug Administration, an agency of POM-like in Indonesia for several types of cancer, although its use to treat mesothelioma are still in experimental stages.
There are about 3000 new cases of mesothelioma cancer are diagnosed each year in the United States, and around the world, and already there are 20 000 people die from this disease every year. Almost all diagnosis of mesothelioma was associated with contact with asbestos, mineral materials that have entered into various commercial products that can be made fire resistant (fireproof). Although the use of asbestos peaked in the 1970s, mesothelioma has a very long latent period for diagnosis and therefore can not be diagnosed in just one year, or even decades after contact.
Unlike the case with chemotherapy and radiation, which tends to have a burning effect on the patient's body, Photodynamic Therapy provides a clear advantage that it does not kill healthy cells-non-cancerous cells. This means that the side effects of cancer treatment can be reduced and certainly mesotelioma mesothelioma prognosis will be better.
In America, Photodynamic Therapy has been approved by the Food and Drug Administration, an agency of POM-like in Indonesia for several types of cancer, although its use to treat mesothelioma are still in experimental stages.
There are about 3000 new cases of mesothelioma cancer are diagnosed each year in the United States, and around the world, and already there are 20 000 people die from this disease every year. Almost all diagnosis of mesothelioma was associated with contact with asbestos, mineral materials that have entered into various commercial products that can be made fire resistant (fireproof). Although the use of asbestos peaked in the 1970s, mesothelioma has a very long latent period for diagnosis and therefore can not be diagnosed in just one year, or even decades after contact.
Sunday, May 23, 2010
Mesothelioma is primary tumors
Mesothalioma are primary tumors that arise from the pleural surface (80% of cases) or peritoneum (20% of cases). Approximately ¾ of a tumor diffuse pleural mesothalioma (usually malign), and the remaining ¼ of the local tumor (usually benign). The ratio of men to women patients than in 3:1. Many studies have confirmed malignant pleural mesothalioma relationship with exposure to asbestos (mainly form crocidolit). Lifetime risk to asbestos workers for the development of malignant pleural mesothalioma approximately 8%. Clinicians should inquire about exposure to asbestos through mining, milling, factory, shipyard workers, insulation, brake shoes, building construction and demolition, roofing materials, and various variations of asbestos products (pipes, textiles, paints, tiles, packaging, boards). Mesothalioma 60-80% of patients reported a history of asbestos exposure. Although cigarette smoking increases the risk of carcinoma broncogenic in asbestos workers and exacerbate asbetosis, there was no relationship between smoking and mesothalioma.
The average age at onset of symptoms mesothalioma approximately 60 years. Latent period between exposure and onset of symptoms is 20-40 years. Its symptoms are not obvious shortening of breath that initially, nonpleuritic chest pain, and weight loss. Physical invention consists of deaf on percussion, decreased breath sounds, and in some cases found the finger drum / clubbing. Radiographic abnormalities consisted of a nodular pleural thickening, irregular, unilateral, and unilateral pleural effusion with varying degrees. CT scans can help show extensive pleural involvement.
Pleural liquid form and often hemorrhagic exudate. opened pleural biopsy is usually necessary to obtain adequate samples for histological diagnosis, although in the end, the distinction from benign inflammatory conditions and adenocarcinoma metastases difficult to do. Variations mesothalioma histology was epithelial and fibrous (sarcomatous). Special staining and electron microscopy is needed to make the diagnosis.
Mesothalioma growing rapidly with the spread of tumor along the pleural surface involving the pericardium, mediastinum, and contralateral pleura. The tumor eventually spread out with the involvement of thoracic lymph node and abdominal organs. Progressive pain and dyspnea typically found. Average survival from onset of symptoms ranges from about 5 months in extensive disease until 16 months at the local disease, and about 75% of patients died in the first years after diagnosis. Therapy with surgery, radiotherapy, chemotherapy, and combinations of these methods has been carried out but no one has succeeded. Some surgeons believe that pneumonectomy ekstrapleural well as surgery performed on patients who are at early stages of disease. Drainage of pleural effusion, pleurodesis, radiation therapy and even surgical resection can provide palliative benefit in some patients.
The average age at onset of symptoms mesothalioma approximately 60 years. Latent period between exposure and onset of symptoms is 20-40 years. Its symptoms are not obvious shortening of breath that initially, nonpleuritic chest pain, and weight loss. Physical invention consists of deaf on percussion, decreased breath sounds, and in some cases found the finger drum / clubbing. Radiographic abnormalities consisted of a nodular pleural thickening, irregular, unilateral, and unilateral pleural effusion with varying degrees. CT scans can help show extensive pleural involvement.
Pleural liquid form and often hemorrhagic exudate. opened pleural biopsy is usually necessary to obtain adequate samples for histological diagnosis, although in the end, the distinction from benign inflammatory conditions and adenocarcinoma metastases difficult to do. Variations mesothalioma histology was epithelial and fibrous (sarcomatous). Special staining and electron microscopy is needed to make the diagnosis.
Mesothalioma growing rapidly with the spread of tumor along the pleural surface involving the pericardium, mediastinum, and contralateral pleura. The tumor eventually spread out with the involvement of thoracic lymph node and abdominal organs. Progressive pain and dyspnea typically found. Average survival from onset of symptoms ranges from about 5 months in extensive disease until 16 months at the local disease, and about 75% of patients died in the first years after diagnosis. Therapy with surgery, radiotherapy, chemotherapy, and combinations of these methods has been carried out but no one has succeeded. Some surgeons believe that pneumonectomy ekstrapleural well as surgery performed on patients who are at early stages of disease. Drainage of pleural effusion, pleurodesis, radiation therapy and even surgical resection can provide palliative benefit in some patients.
Friday, May 21, 2010
Mesothelioma Treatment
Treatment program for mesothelioma depends on many factors, such as: stage of cancer, where cancer is, how far the cancer has spread, how the cancer cells look under a microscope, the patient's age and psychological patients.
People who are diagnosed with this disease are often said to only have the ability to survive eight to twelve months. However, specialists in dealing with malignant mesothelioma at leading cancer centers often have better statistics.
For example, the survival rate in five years has approached 40% for patients who selected Dr. David Sugarbaker at Brigham and Women's Center in Boston. To qualify to receive Dr. Sugarbaker's treatment you must meet certain criteria. One is the disease is still in its early stages.
There are three types of treatment are usually done for patients who develop malignant mesothelioma:
* Surgery (take it out)
* Chemotherapy (using medicines to fight cancer)
* Radiation Therapy (using high-dose x-rays or high energy rays to kill cancer cells)
Often two or more from this combined treatment.
Thoracoscopy enables a physician to evaluate the pleural space and to perform biopsy of some tissue under direct vision. At up to 98% of cases, definitive diagnosis can be obtained. Often, chemical pleurodesis aimed at reducing the accumulation of fluid in the intrapleural space, can be achieved during the same procedure. It is also possible to measure the extent of the tumor, and make a determination of surgical resectability. While less invasive than open biopsy, can only be performed in patients where the tumor is not removed pleural space.
thoracic surgery with the help of the video is an alternative to thoracoscopy, although because it is more invasive, concerns of tumor seeding increases. By utilizing small incisions, doctors can view the pleural space with the aid of a camera, and obtain adequate tissue samples for analysis by a pathologist. Level of tumor (eg, pleural involvement, chest wall invasion) may also be determined, and recommendations for the type of significant procedures required can be made at this time.
Mediastinoscopy is sometimes used as an aid in the rate of disease stage when enlarged nodes seen using imaging techniques.
Laproscopy used on mesothelioma patients in cases where imaging techniques suggest the possibility of tumor invasion through the diaphragm. This information can be important in evaluating a patient for potential pleurectomy or extrapleural pneumonectomy.
People who are diagnosed with this disease are often said to only have the ability to survive eight to twelve months. However, specialists in dealing with malignant mesothelioma at leading cancer centers often have better statistics.
For example, the survival rate in five years has approached 40% for patients who selected Dr. David Sugarbaker at Brigham and Women's Center in Boston. To qualify to receive Dr. Sugarbaker's treatment you must meet certain criteria. One is the disease is still in its early stages.
There are three types of treatment are usually done for patients who develop malignant mesothelioma:
* Surgery (take it out)
* Chemotherapy (using medicines to fight cancer)
* Radiation Therapy (using high-dose x-rays or high energy rays to kill cancer cells)
Often two or more from this combined treatment.
Thoracoscopy enables a physician to evaluate the pleural space and to perform biopsy of some tissue under direct vision. At up to 98% of cases, definitive diagnosis can be obtained. Often, chemical pleurodesis aimed at reducing the accumulation of fluid in the intrapleural space, can be achieved during the same procedure. It is also possible to measure the extent of the tumor, and make a determination of surgical resectability. While less invasive than open biopsy, can only be performed in patients where the tumor is not removed pleural space.
thoracic surgery with the help of the video is an alternative to thoracoscopy, although because it is more invasive, concerns of tumor seeding increases. By utilizing small incisions, doctors can view the pleural space with the aid of a camera, and obtain adequate tissue samples for analysis by a pathologist. Level of tumor (eg, pleural involvement, chest wall invasion) may also be determined, and recommendations for the type of significant procedures required can be made at this time.
Mediastinoscopy is sometimes used as an aid in the rate of disease stage when enlarged nodes seen using imaging techniques.
Laproscopy used on mesothelioma patients in cases where imaging techniques suggest the possibility of tumor invasion through the diaphragm. This information can be important in evaluating a patient for potential pleurectomy or extrapleural pneumonectomy.
Wednesday, May 19, 2010
Malignant Mesothelioma
Malignancy involving the mesothelial cells of the human body, including the pleura, peritoneum, pericardium, and testis, known as malignant mesothelioma, whether local or diffuse. Most, but not all, cases of malignant mesothelioma (malignant mesothelioma) in the pleural (lung cancer) is usually associated with exposure to asbestos. Patients with malignant pleural mesothelioma, 77% had been exposed to the asbestos in the past. Diagnosis of mesothelioma is difficult to enforce because the results of the analysis of fluid effusion of cancer is usually not terdiagnostik. Mesothelioma is more common in men than women and it occurs most often in the fifth decade of age until the seventh decade. Most cases (about 90%) of malignant pleural mesothelioma occurs at.
From the picture there are three types of mesothelioma histologinya of sarcomatous mesothelioma, epithelial, and mixed (mixed). Pleural mesothelioma usually begins as plaques and nodules which combine to produce sheetlike neoplasm. Tumor growth usually begins in the lower chest. The tumor can invade the diaphragm and lung surface covered and the gap interlobaris.
When developing the disease, often spread to the lung parenchyma, chest wall and the wall of the mediastinum. Pleural mesothelioma can spread into the esophagus, ribs, spine, brachial plexus, and superior vena cava.
Asbestos, amphibole asbestos, asbestos-crocidolite, and amosite asbestos in particular, is involved in the pathogenesis of primary carcinogen. Chrysotile asbestos exposure was associated with a lower incidence of mesothelioma. Industrial areas with the occurrence of frequent be told mesotelioma due to asbestos exposure, including mining, ship building which involves the use of asbestos, asbestos cement manufacturing, ceramics, paper mill, auto parts, and repair factory train. Clinical manifestations / symptoms that occurred in mesothelioma clinics are: * nonpleuritic dyspnea and chest wall pain is the most common symptoms that occur in malignant mesothelioma. (Approximately 60-90% of patients had symptoms of chest pain or dyspnea.) * In patients with malignant mesothelioma, pleural effusion physical findings are usually known by percussion and auscultation. * In rare cases, malignant mesothelioma manifests as cord compression, brachial plexopathy, Horner syndrome, or superior vena cava syndrome. Death is usually caused by infection or respiratory failure in the development of mesothelioma. * The main area that often occurs in the pleura (87%), peritoneum (5.1%), and the pericardium (0.4%).
Prognosis of Mesothelioma
Approximately 2000 until 3000 the most recent case was diagnosed with cancer, mesothelioma in the United States each year. After the patient is diagnosed, your doctor will likely discuss their prognosis. The best way to avoid poor prognosis mesothelioma is through early detection. discusses the factors associated with prognosis of mesothelioma in this blog will be described in further detail as follows.
What are the factors that influence the prognosis of mesothelioma?
Mesothelioma is generally not diagnosed until late stages of development. In addition, symptoms of mesothelioma are very common and often resemble less serious conditions, which can make it difficult to diagnose cancer. As a result, the prognosis for the majority of patients is lacking, but many doctors may recommend surgical treatment options such as mesothelioma, chemotherapy and radiation to help fight the disease.
Mesothelioma cancer, there are several stages, starting from stage one to stage four. Unfortunately, once mesothelioma cancer has reached stage three or four, not only treatment options become more limited, but less effective as well.
In addition to the cancer stage and patient age, other factors that affect prognosis include:
* Types of mesothelioma - pleural mesothelioma, peritoneal mesothelioma, pericardial mesothelioma or testicular mesothelioma
* Size of tumor
* Location of mesothelioma tumor and whether it can be done with surgery
* Level of other symptoms, including fluid in the lungs or stomach
* Is the patient a smoker or not
Malignant mesothelioma cancer is usually diagnosed in individuals over 55 years, although there are certainly exceptions. Some patients already have multiple medical problems caused by old age, making treatment more difficult and increase worse prognosis of mesothelioma patients
What are the factors that influence the prognosis of mesothelioma?
Mesothelioma is generally not diagnosed until late stages of development. In addition, symptoms of mesothelioma are very common and often resemble less serious conditions, which can make it difficult to diagnose cancer. As a result, the prognosis for the majority of patients is lacking, but many doctors may recommend surgical treatment options such as mesothelioma, chemotherapy and radiation to help fight the disease.
Mesothelioma cancer, there are several stages, starting from stage one to stage four. Unfortunately, once mesothelioma cancer has reached stage three or four, not only treatment options become more limited, but less effective as well.
In addition to the cancer stage and patient age, other factors that affect prognosis include:
* Types of mesothelioma - pleural mesothelioma, peritoneal mesothelioma, pericardial mesothelioma or testicular mesothelioma
* Size of tumor
* Location of mesothelioma tumor and whether it can be done with surgery
* Level of other symptoms, including fluid in the lungs or stomach
* Is the patient a smoker or not
Malignant mesothelioma cancer is usually diagnosed in individuals over 55 years, although there are certainly exceptions. Some patients already have multiple medical problems caused by old age, making treatment more difficult and increase worse prognosis of mesothelioma patients
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